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ChemicalBook CAS DataBase List 2-(ChloroMethyl)-4-Methylpyridine hydrochloride

2-(ChloroMethyl)-4-Methylpyridine hydrochloride synthesis

9synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.5 h / 100 °C / Inert atmosphere; Reflux
2: hydrogenchloride / water / 1 h / Inert atmosphere; Reflux
3: thionyl chloride / 0.5 h / Inert atmosphere; Reflux

References:

Stock, Nicholas S.;Bain, Gretchen;Zunic, Jasmine;Li, Yiwei;Ziff, Jeannie;Roppe, Jeffrey;Santini, Angelina;Darlington, Janice;Prodanovich, Pat;King, Christopher D.;Baccei, Christopher;Lee, Catherine;Rong, Haojing;Chapman, Charles;Broadhead, Alex;Lorrain, Dan;Correa, Lucia;Hutchinson, John H.;Evans, Jilly F.;Prasit, Peppi [Journal of Medicinal Chemistry,2011,vol. 54,# 23,p. 8013 - 8029]