2-(CHLOROMETHYL)-5-(4-IODOPHENYL)-1,3,4-OXADIAZOLE synthesis
- Product Name:2-(CHLOROMETHYL)-5-(4-IODOPHENYL)-1,3,4-OXADIAZOLE
- CAS Number:623907-47-1
- Molecular formula:C9H6ClIN2O
- Molecular Weight:320.51
53324-36-0
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Yield:623907-47-1 59%
Reaction Conditions:
at 95; for 3 h;
Steps:
7
5- (4-Iodophenyl)-lH-tetrazole (l. OOg, 3.68mmol) and chloroacetic anhydride (3.77g, 22. 1mmol) were heated at 95°C for 3 hours. The crude product was purified on a lOg silica SPE cartridge with 5: 95 ethyl acetate: cyclohexane to 20: 80 ethyl acetate: cyclohexane. The desired product crystallised spontaneously. The title compound was isolated as white crystals, which were filtered off and washed with cold cyclohexane (690mg, 59%) NMR: §H CDC13 7.89 (2H, d), 7.80 (2H, d), 4.78 (2H, s) ppm. LCMS: retention time 3.23 min, MH+ 321.
References:
WO2003/93248,2003,A1 Location in patent:Page/Page column 22