ChemicalBook CAS DataBase List 2-(ChloroMethyl)-5-Methylpyridine hydrochloride

2-(ChloroMethyl)-5-Methylpyridine hydrochloride synthesis

7synthesis methods

Product Name:2-(ChloroMethyl)-5-Methylpyridine hydrochloride
CAS Number:71670-70-7
Molecular formula:C7H9Cl2N
Molecular Weight:178.06

22940-71-2 Synthesis

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2-(ChloroMethyl)-5-Methylpyridine hydrochloride

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Yield: 91.3%

Reaction Conditions:

with thionyl chloride for 0.5 h;Reflux;

Steps:

50.3 2-(chloromethyl)- -methylpyridine hydrochloride
2-(chloromethyl)- -methylpyridine hydrochloride A solution of (5-methylpyridin-2-yl)methanol in SOCl₂ (10 mL) was refluxed 30 min. The mixture was concentrated and dried in vacuo to give 2-(chloromethyl)-5-methylpyridine hydrochloride (2. lg, 91.3% yield) as white solid. LCMS MH⁺ 142.

References:

HYDRA BIOSCIENCES, INC.;CHENARD, Bertrand;GALLASCHUN, Randall WO2014/143799, 2014, A2 Location in patent:Page/Page column 408; 409

22940-71-2 Synthesis

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$45.00/50mg