![](/CAS/GIF/156144-42-2.gif)
2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE synthesis
- Product Name:2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE
- CAS Number:156144-42-2
- Molecular formula:C8H6ClFN2
- Molecular Weight:184.6
![3,4-Diaminofluorobenzene](/CAS/GIF/367-31-7.gif)
367-31-7
217 suppliers
$8.00/1g
![Chloroacetic acid](/CAS/GIF/79-11-8.gif)
79-11-8
10 suppliers
$27.00/25g
![2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE](/CAS/GIF/156144-42-2.gif)
156144-42-2
44 suppliers
$45.00/50mg
Yield:156144-42-2 86%
Reaction Conditions:
Stage #1: 4-fluoro-1,2-phenylenediamine;chloroacetic acidwith water in water at 95; for 6 h;
Stage #2: with sodium hydrogencarbonate in water; pH=9;
Steps:
A30.a
A mixture of 4-fluoro-l,2-phenylenediamine (1.26 g, 10.0 mmol) and chloroacetic acid (1.23 g, 13.0 mmol) in HCl (6 M, 7 ml) was stirred at 95 0C for 6 hours. The reaction mixture was neutralized with saturated aqueous NaHCO3 solution (pH = 9) and the precipitated material was collected, washed with H2O and dried under reduced pressure at 65 °C to give 2-(chloromethyl)-5-fluoro-lH-benzo[d]imidazole (1.58 g,86 %, off-white solid)
References:
WO2008/8398,2008,A2 Location in patent:Page/Page column 365
![1H-Benzimidazole-2-methanol,5-fluoro-(9CI)](/CAS/GIF/39811-07-9.gif)
39811-07-9
73 suppliers
$26.00/250mg
![2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE](/CAS/GIF/156144-42-2.gif)
156144-42-2
44 suppliers
$45.00/50mg
![3,4-Diaminofluorobenzene](/CAS/GIF/367-31-7.gif)
367-31-7
217 suppliers
$8.00/1g
![2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE](/CAS/GIF/156144-42-2.gif)
156144-42-2
44 suppliers
$45.00/50mg