2-chloromethyloxetane synthesis

Yield:45377-87-5 80.5%

Reaction Conditions:

with potassium chloride in 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 200;

Steps:

2 Example 2: Synthesis of 2-chloromethyloxetane

12.1 g of Compound 2 was dissolved in 2 mL/g of triethylene glycol at room temperature.Add 14.9g of potassium chloride, distillate under reduced pressure, and slowly increase the temperature of the oil bath to 200 ° C.The reaction solution was washed and dried over anhydrous sodium sulfate.After concentration, compound 3 (2-chloromethyl) is obtained.Oxetane) 4.3 g, yield 80.5%.

References:

CN108947940,2018,A Location in patent:Paragraph 0043; 0044; 0045