2-cyano-N-(2-ethylphenyl)acetamide synthesis
2synthesis methods
- Product Name:2-cyano-N-(2-ethylphenyl)acetamide
- CAS Number:87165-08-0
- Molecular formula:C11H12N2O
- Molecular Weight:188.23
Yield:87165-08-0 81%
Reaction Conditions:
Stage #1: cyanoacetic acidwith phosphorus pentachloride in dichloromethane; for 0.5 h;Reflux;
Stage #2: ortho-ethylaniline in dichloromethane; for 2 h;Reflux;
References:
Hazeldine, Stuart;Pachaiyappan, Boobalan;Steinbergs, Nora;Nowotarski, Shannon;Hanson, Allison S.;Casero, Robert A.;Woster, Patrick M. [Journal of Medicinal Chemistry,2012,vol. 55,# 17,p. 7378 - 7391]
