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2-CYANO-N-[2-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE synthesis

2synthesis methods
-

Yield:419534-37-5 89%

Reaction Conditions:

Stage #1: cyanoacetic acidwith phosphorus pentachloride in dichloromethane; for 0.5 h;Reflux;
Stage #2: 2-(trifluoromethyl)benzenamine in dichloromethane; for 2 h;Reflux;

References:

Hazeldine, Stuart;Pachaiyappan, Boobalan;Steinbergs, Nora;Nowotarski, Shannon;Hanson, Allison S.;Casero, Robert A.;Woster, Patrick M. [Journal of Medicinal Chemistry,2012,vol. 55,# 17,p. 7378 - 7391]