2-CYANO-N,N-DIPROPYLACETAMIDE synthesis
- Product Name:2-CYANO-N,N-DIPROPYLACETAMIDE
- CAS Number:53807-35-5
- Molecular formula:C9H16N2O
- Molecular Weight:168.24
Yield:53807-35-5 89%
Reaction Conditions:
with N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in dichloromethane;N,N-dimethyl-formamide at 20;
Steps:
6 Preparation of 2-cyano-N,N-dipropylacetamide
Dipropylamine (1.84 ml, 13.43 mmol, 2.5 eq.) and 2-cyanoacetic acid (0.46 g, 5.37 mmol, 1 eq.) were combined in a mixture of 4 ml DCM and 2 ml DMF. HATU (1- [Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate, Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) (3.06 mg, 8.06 mmol, 1.5 eq.) was added and the reaction stirred at room temperature. Upon completion, the reaction mixture was concentrated and purified by preparatory HPLC to give 2-cyano-N,N- dipropylacetamide as a light brown oil (0.80 g, 4.76 mmol, 89% yield). LC/MS [M+H] 169.13 (calculated); LC/MS [M+H] 169.09 (observed).
References:
WO2021/46112,2021,A1 Location in patent:Page/Page column 64
