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2-CYANO-N-O-TOLYL-ACETAMIDE synthesis

3synthesis methods
-

Yield:59736-34-4 94%

Reaction Conditions:

Stage #1: 2-cyanoacetic acidwith phosphorous pentachloride in dichloromethane; for 0.5 h;Reflux;
Stage #2: o-toluidine in dichloromethane; for 2 h;Reflux;

References:

Hazeldine, Stuart;Pachaiyappan, Boobalan;Steinbergs, Nora;Nowotarski, Shannon;Hanson, Allison S.;Casero, Robert A.;Woster, Patrick M. [Journal of Medicinal Chemistry,2012,vol. 55,# 17,p. 7378 - 7391]

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