2-cyclopropylethyl methanesulfonate synthesis

Yield:124217-77-2 100%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 2 h;

Steps:

2.1 Step 1: 2-cyclopropyl ethyl methanesulfonyl ester

In a 250mL two-neck flask, add 2-cyclopropyl ethanol (6.5g, 75.5mmol),Triethylamine (15mL, 106mmol)And dichloromethane (100mL), then cool to 0°C,Slowly add methanesulfonyl chloride (7.01mL, 90.6mmol) dropwise, after the addition, continue stirring at 0°C for 2h.Post-treatment: add water (50mL) to wash, DCM extraction three times (50mL×3), combine the organic phases, wash the organic phase with saturated brine (30mL×3),Spin to dryness and concentrate to obtain the title compound as a colorless oily liquid (12.4 g, 100%).

References:

CN111217811,2020,A Location in patent:Paragraph 0287-0291