![](/CAS/GIF/7024-58-0.gif)
2-Cyclopropylpyrimidine-4,6-diol synthesis
- Product Name:2-Cyclopropylpyrimidine-4,6-diol
- CAS Number:7024-58-0
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
![Cyclopropane-1-carboximidamide hydrochloride](/CAS/GIF/57297-29-7.gif)
57297-29-7
202 suppliers
$8.00/1g
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
733 suppliers
$5.00/25g
![2-Cyclopropylpyrimidine-4,6-diol](/CAS/GIF/7024-58-0.gif)
7024-58-0
21 suppliers
$45.00/10mg
Yield:7024-58-0 96%
Reaction Conditions:
Stage #1: cyclopropylcarboxamidine hydrochloridewith methanol;sodium for 0.25 h;Cooling with ice;
Stage #2: diethyl malonate in methanol at 20;Cooling with ice;
Stage #3: with hydrogenchloride in water; pH=5;
Steps:
1
2-Cyclopropylpyrimidine-4,6-diol (2) Sodium metal (5.83 g, 254 mmol) was added to anhydrous methanol (100 mL) cooled in an ice bath. Once sodium methoxide formation was complete (all sodium dissolved), cyclopropyl carboxamidine hydrochloride (10.0 g, 80 mmol) was added and reaction mixture was stirred for 15 min. Diethyl malonate (12.6 imL, 82.9 mmol) was added dropwise and the reaction mixture was warmed to RT and stirred overnight. The suspension was then concentrated under vacuum. The resulting residue was dissolved in water and the solution was acidified with concentrated HCI to pH 5. The resulting precipitate was collected via filtration and washed sequentially with water, ether, isopropanol, and finally ether. The solid was then dried under vacuum to afford 11 .69 g (96 %) of 2-cyclopropylpyrimidine-4,6- diol (2). LCMS m/z 153.4 (M+1 ). H NMR (400 MHz, DMSO-d6) δ 1 1 .87 (s, 2H), 5.03 (s, 1 H), 1.86 (m, 1 H), 0.98 (m, 4H).
References:
WO2011/58478,2011,A1 Location in patent:Page/Page column 30-31
![Cyclopropane-1-carboximidamide hydrochloride](/CAS/GIF/57297-29-7.gif)
57297-29-7
202 suppliers
$8.00/1g
![Dimethyl malonate](/CAS/GIF/108-59-8.gif)
108-59-8
580 suppliers
$5.00/25g
![2-Cyclopropylpyrimidine-4,6-diol](/CAS/GIF/7024-58-0.gif)
7024-58-0
21 suppliers
$45.00/10mg
![CYCLOPROPANECARBOXAMIDINE](/CAS/GIF/54070-74-5.gif)
54070-74-5
60 suppliers
$60.00/1g
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
733 suppliers
$5.00/25g
![2-Cyclopropylpyrimidine-4,6-diol](/CAS/GIF/7024-58-0.gif)
7024-58-0
21 suppliers
$45.00/10mg
![Malonamide](/CAS/GIF/108-13-4.gif)
108-13-4
261 suppliers
$9.00/1g
![Ethyl cyclopropanecarboxylate](/CAS/GIF/4606-07-9.gif)
4606-07-9
134 suppliers
$10.00/1g
![2-Cyclopropylpyrimidine-4,6-diol](/CAS/GIF/7024-58-0.gif)
7024-58-0
21 suppliers
$45.00/10mg