ChemicalBook CAS DataBase List 2-difluoroMethylbenzoic acid

2-difluoroMethylbenzoic acid synthesis

6synthesis methods

Product Name:2-difluoroMethylbenzoic acid
CAS Number:799814-32-7
Molecular formula:C8H6F2O2
Molecular Weight:172.13

Benzoic acid,1-(difluoromethyl)-methyl ester

1018678-48-2
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$127.00/500mg

799814-32-7
52 suppliers
$45.00/100mg

Yield:799814-32-7 93%

Reaction Conditions:

with lithium hydroxide monohydrate;sodium hydroxide for 0.5 h;Reflux;

Steps:

103.2 Synthesis of 2-(difluoromethyl)benzoic acid:

A mixture of methyl 2-(difluoromethyl)benzoate (7.0 g, 38 mmol) and 10% aq. NaOH (100 mL) in MeOH (50 mL) was heated at reflux for 30 min. The pH was adjusted to 4 the addition of 3N HC1. The resulting solid was collected by filtration, rinsed with H₂O and dried to give 2-(difluoromethyl)benzoic acid (6.0 g, 93 % yield).

References:

WO2013/59587,2013,A1 Location in patent:Page/Page column 190; 191

118-90-1 Synthesis