2-(dimethoxymethylidene)propanedinitrile synthesis
- Product Name:2-(dimethoxymethylidene)propanedinitrile
- CAS Number:64672-72-6
- Molecular formula:C6H6N2O2
- Molecular Weight:138.12
Yield:64672-72-6 76%
Reaction Conditions:
with urea in diethyl ether at -78; for 1.83333 h;
Steps:
142.1 Step 1: (2-(Dimethoxymethylene)malononitrile)
The reaction mixture of ethene-1,1,2,2-tetracarbonitrile (10.23 g, 80 mmol), urea (1.439 g, 23.96 mmol) and methanol (30.7 ml, 759 mmol) was stirred for 50 minutes. Ether (150 mL) was added to the reaction mixture, then cooled to -78 °C with stirring for 60 minutes. The solid was filtered and washed with cold ether/hexane to afford 2- (dimethoxymethylene)malononitrile (8.35 g, 60.5 mmol, 76% yield) as a pale yellow solid. LCMS m/z = 138.9 [M+H]+.
References:
WO2017/216726,2017,A1 Location in patent:Page/Page column 707-708
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