ChemicalBook CAS DataBase List 2-(Diphenylphosphino)-biphenyl

2-(Diphenylphosphino)-biphenyl synthesis

14synthesis methods

Product Name:2-(Diphenylphosphino)-biphenyl
CAS Number:13885-09-1
Molecular formula:C24H19P
Molecular Weight:338.38

2052-07-5 Synthesis

2052-07-5
381 suppliers
$16.30/1g

1079-66-9
423 suppliers
$5.00/5g

13885-09-1
184 suppliers
$6.00/250mg

Yield:13885-09-1 79%

Reaction Conditions:

Stage #1:2-Bromobiphenyl with n-butyllithium in diethyl ether;hexane at -15;Inert atmosphere;
Stage #2:chloro-diphenylphosphine in diethyl ether;hexane at 20; for 3 h;Cooling;Inert atmosphere;

Steps:

17 Reference Example 17
Under argon atmosphere, 2-bromobiphenyl (1.40 g, 6.00 mmol) was dissolved into diethyl ether (10 mL), and [the obtainment] was cooled down to -15° C.
In to this solution, n-butyllithium in a 2.67M hexane solution (2.4 mL, 6.41 mmol) was delivered by drops, and after stirring for 2 hours, chlorodiphenylphosphine in a 0.54M diethyl ether solution (10 mL, 5.4 mmol) was added, and [the mixture] was slowly heated to room temperature and stirred for 3 hours.
The reaction liquid was filtrated, and the filtrate was concentrated under reduced pressure, and the obtained crude product was refined by silica gel column chromatography (eluent: hexane/ethyl acetate), and then, a white solid of (2-biphenyl) diphenyl phosphine was obtained (yield amount: 1.6 g, yield: 79%).
¹H-NMR (400 MHz, CDCl₃), δ (ppm): 7.41˜7.37 (m, 1H), 7.34˜7.16 (m, 17H), 7.07˜7.04 (m, 1H).
³¹P-NMR (162 MHz, CDCl₃), δ (ppm): -13.5 (s).

References:

TOSOH CORPORATION;SAGAMI CHEMICAL RESEARCH INSTITUTE;ARAKI, Keisuke;HONDA, Hiroya;KOISO, Naoyuki;NAKAGAME, Ryo;YOSHITOMI, Fumiaki;IWANAGA, Kohei;FURUKAWA, Taishi US2020/354389, 2020, A1 Location in patent:Paragraph 0345

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2113-51-1 Synthesis