2-Ethyl-5-(trifluoromethyl)benzenamine synthesis
- Product Name:2-Ethyl-5-(trifluoromethyl)benzenamine
- CAS Number:1369923-98-7
- Molecular formula:C9H10F3N
- Molecular Weight:189.18
1553981-34-2
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1369923-98-7
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Yield:1369923-98-7 92%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in tetrahydrofuran at 20; under 2068.65 Torr; for 8 h;
Steps:
G.2 Step 2: 2-Ethyl-5.(trlfluorcmethyl)anlllne
Step 2: 2-Ethyl-5.(trlfluorcmethyl)anlllne Step 2: 2-Ethyl-5.(trlfluorcmethyl)anlllneI-Ethenyl-2-nitro.4-(tiifluoromethyQbenzene (22 g, 10.13 mmd) dissolved in ThF (150 mL) was shaked at room temperatureunderH2(4Opsi)inthepresenceofl0%PdIC(200mg)for8h.Thereacdonmbcturewasfiltered through a pad of Celite, washed with EtOAc, and the liMe was concentrated. The residue was purified by flash chromatography (hexanelEtOAc WI) to afford the title compound (1.76 g, 92%).‘H NMR (600 MHz, DM80.4) 87.10 (d, J = 7.7 Hz, IH), 6.89 (d, J = 1.5 Hz, IH), 6.61 -6.81 (d, J = 7.7 Hz, IH),5.30 (s, 2H), 2.48 (q, J= 7.5 Hz, 2 H), 1.13 (t, J= 7.5 Hz, 3H).
References:
WO2014/19908,2014,A2 Location in patent:Page/Page column 33
349-03-1
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