(2-ETHYL-PHENOXY)-ACETIC ACID synthesis
- Product Name:(2-ETHYL-PHENOXY)-ACETIC ACID
- CAS Number:1798-03-4
- Molecular formula:C10H12O3
- Molecular Weight:180.2
100256-84-6
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1798-03-4
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Yield:-
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran
Steps:
4.7 General procedure F for the hydrolysis of esters to acid
General procedure: To the solution of acetate/propanoate in THF:H2O (1:1) was added 2.0 equiv of LiOH, and stirred for 2-3hrs. When the ester was fully consumed, THF was evaporated and aq.NaHCO3 was added and worked up with ethyl acetate. Organic layer was discarded and the pH of aqueous layer was adjusted to 2. Then the acid was extracted with ethyl acetate. Ethyl acetate extracts were dried over sodium sulfate and was concentrated to give off-white to white solids.
References:
Ali, Kasim;Chaturvedi, Priyank;Datta, Dipak;Kumar M, Srinivas Lavanya;Meena, Sanjeev;Panda, Gautam [Journal of Molecular Structure,2021,vol. 1225]
