ChemicalBook CAS DataBase List 2-ethynylpyrazine

2-ethynylpyrazine synthesis

2synthesis methods

Product Name:2-ethynylpyrazine
CAS Number:153800-11-4
Molecular formula:C6H4N2
Molecular Weight:104.11

291763-66-1
4 suppliers
inquiry

153800-11-4
57 suppliers
$45.00/10mg

Yield: 56.5%

Reaction Conditions:

with tetrabutyl ammonium fluoride in tetrahydrofuran for 0.05 h;

Steps:

3 Procedure for preparation of2ethyny1pyraziaie:
To a solution of 9(3.Og, 17.O2rnrnoi) in iOmL THE was added IM of TBAF over 3 minutes. TLC analysis showed complete conversion of starting material to a major product. The reactionmixture was then concentrated in vacuo. The crude product was purified by silica gel column chromatography to give product 10(1.0g. yield: 56.5%).LCMS: m/ 105 (M+H).

References:

HUA MEDICINE (SHANGHAI) LTD.;CHEN, Li;JIN, Xiaowei WO2017/117708, 2017, A1 Location in patent:Page/Page column 18; 19

3-Butyn-2-ol, 2-methyl-4-pyrazinyl- (9CI)

904694-67-3
0 suppliers
inquiry

153800-11-4
57 suppliers
$45.00/10mg

References