2-ethyoxyl-4-broMobenzonitrile synthesis

Yield:1255870-63-3 94%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide;

Steps:

43 (Experimental Method 1) 2-Ethoxy-4-bromo-benzonitrile

4-fluoro-2-hydroxybenzonitrile (50 mg, 0.32 mmol) and DMF (2 ml) were put in a round-bottom flask and stirred, finely ground potassium carbonate (133 mg, 0.96 mmol) was added thereto, and then iodoethane (0.03 ml, 0.39 mmol) was added thereto, followed by stirring.
After confirming by TLC that the base compound had disappeared, DMF was vacuum-distilled, and the residue was diluted with ethyl acetate and then washed with brine.
The residue obtained after vacuum distillation was subjected to column chromatography (hexane:ethyl acetate=5:1) to obtain 2-ethoxy-4-bromo-benzonitrile (53.8 mg).
(Yield: 94%)

References:

US2018/265462,2018,A1 Location in patent:Paragraph 0151