2-Fluoro-1-(2-methoxyethoxy)-4-nitrobenzene synthesis

4synthesis methods

Product Name:2-Fluoro-1-(2-methoxyethoxy)-4-nitrobenzene
CAS Number:221198-59-0
Molecular formula:C9H10FNO4
Molecular Weight:215.18

403-19-0 Synthesis

403-19-0
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$6.00/5g

6482-24-2 Synthesis

6482-24-2
282 suppliers
$9.00/1g

2-Fluoro-1-(2-methoxyethoxy)-4-nitrobenzene

221198-59-0
7 suppliers
$740.00/5g

Yield:221198-59-0 95.81%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 70 - 75; for 3 h;

Steps:

23 Synthesis of 2-fluoro-1-(2-methoxyethoxy)-4-nitrobenzene (1)

A mixture of 2-fluoro-4-nitrophenol (7.940 g, 50.57 mmol), 1-bromo-2-methoxyethane (7.656 g, 55.09 mmol), K₂CO₃ (13.880 g, 100.57 mmol) in DMF (50 mL) was stirred at 70-75 for 3 h until TLC (DCM/MeOH = 50/1 as mobile phase) indicated the completion of the reaction. The mixture was allowed to cool down to room temperature and then poured onto ice water (180 mL). The yellow precipitate was collected, washed with water (100 mL) and dried under vacuum for 5 hours to afford 2-fluoro-1-(2-methoxyethoxy)-4-nitrobenzene 1 (10.33 g, 95.81%).

References:

WO2015/6754,2015,A2 Location in patent:Paragraph 00279

6482-24-2 Synthesis

6482-24-2
282 suppliers
$9.00/1g

22510-08-3 Synthesis