2-FLUORO-1-(METHYLSULFONYL)-4-NITROBENZENE synthesis
1synthesis methods
- Product Name:2-FLUORO-1-(METHYLSULFONYL)-4-NITROBENZENE
- CAS Number:252561-33-4
- Molecular formula:C7H6FNO4S
- Molecular Weight:219.19
Yield:252561-33-4 79%
Reaction Conditions:
in dimethyl sulfoxide at 60; for 3 h;
Steps:
5 Example 5 3-fluoro-4-methanesulfonylnitrobenzene
8g of 3, 4-DIFLUORONITROBENZENE and 1. 01EQ of sodium methanesulfinate (95%) was dissolved in 10MOI of DMSO. The solution was stirred at 60C for 3 hours. When the reaction was completed, the solution was added to 100ML of water to form pale yellow solid, followed by filtration and washing with 50ML of cool water and 30ML of n-hexane separately to give 8.8g of the title compound as a pale yellow solid (yield 79%). Mass (LOW EL) = 219.0
References:
WO2004/46121,2004,A1 Location in patent:Page 16-17