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2-Fluoro-3-methoxyphenylacetic acid synthesis
- Product Name:2-Fluoro-3-methoxyphenylacetic acid
- CAS Number:863645-29-8
- Molecular formula:C9H9FO3
- Molecular Weight:184.16
![Benzeneacetonitrile, 2-fluoro-3-methoxy- (9CI)](/CAS/GIF/672931-80-5.gif)
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![2-Fluoro-3-methoxyphenylacetic acid](/CAS/20200331/GIF/863645-29-8.gif)
863645-29-8
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$45.00/10mg
Yield:863645-29-8 96.4%
Reaction Conditions:
with sodium hydroxide in ethanol;water at 40 - 100;
Steps:
5 Example 5
Compound V (40.2 g, 0.24 mmol), ethanol (200 mL),Water (200 mL), sodium hydroxide (29.2 g, 0.73 mol) was added, and the temperature was raised to 40-100 ° C until the reaction was completed. Concentrated ethanol, washed with methyl tert-butyl ether, lowered the temperature to 0 to 10 ° C, adjusted the pH to 3 to 4 with dilute hydrochloric acid, and filtered and dried to obtain a light brown solid.Compound VI (43.2 g, 96.4%).
References:
CN110759870,2020,A Location in patent:Paragraph 0092; 0119; 0128-0129
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![Benzenemethanol, 2-fluoro-3-methoxy- (9CI)](/CAS/GIF/178974-59-9.gif)
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863645-29-8
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$45.00/10mg
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$14.14/250mgs:
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863645-29-8
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![2-Fluoro-3-methoxyphenylacetic acid](/CAS/20200331/GIF/863645-29-8.gif)
863645-29-8
11 suppliers
$45.00/10mg