2-Fluoro-3-methoxyphenylacetic acid synthesis

7synthesis methods

Product Name:2-Fluoro-3-methoxyphenylacetic acid
CAS Number:863645-29-8
Molecular formula:C9H9FO3
Molecular Weight:184.16

Benzeneacetonitrile, 2-fluoro-3-methoxy- (9CI)

672931-80-5
8 suppliers
inquiry

863645-29-8
11 suppliers
$45.00/10mg

Yield:863645-29-8 96.4%

Reaction Conditions:

with sodium hydroxide in ethanol;water at 40 - 100;

Steps:

5 Example 5

Compound V (40.2 g, 0.24 mmol), ethanol (200 mL),Water (200 mL), sodium hydroxide (29.2 g, 0.73 mol) was added, and the temperature was raised to 40-100 ° C until the reaction was completed. Concentrated ethanol, washed with methyl tert-butyl ether, lowered the temperature to 0 to 10 ° C, adjusted the pH to 3 to 4 with dilute hydrochloric acid, and filtered and dried to obtain a light brown solid.Compound VI (43.2 g, 96.4%).

References:

CN110759870,2020,A Location in patent:Paragraph 0092; 0119; 0128-0129

2,2,2-Trichloro-1-(2-fluoro-3-methoxyphenyl)ethanol

1418126-60-9
2 suppliers
inquiry

863645-29-8
11 suppliers
$45.00/10mg

References

Benzenemethanol, 2-fluoro-3-methoxy- (9CI)

178974-59-9
38 suppliers
$44.00/1g

863645-29-8
11 suppliers
$45.00/10mg

References

103438-88-6
154 suppliers
$14.14/250mgs:

863645-29-8
11 suppliers
$45.00/10mg

References

1-(Chloromethyl)-2-fluoro-3-methoxybenzene

178974-63-5
7 suppliers
inquiry

863645-29-8
11 suppliers
$45.00/10mg

References