![](/CAS/GIF/101969-75-9.gif)
2-FLUORO-4'-HYDROXYBENZOPHENONE synthesis
- Product Name:2-FLUORO-4'-HYDROXYBENZOPHENONE
- CAS Number:101969-75-9
- Molecular formula:C13H9FO2
- Molecular Weight:216.21
![2-FLUORO-4'-METHOXYBENZOPHENONE](/CAS/GIF/66938-29-2.gif)
66938-29-2
36 suppliers
$294.00/1g
![2-FLUORO-4'-HYDROXYBENZOPHENONE](/CAS/GIF/101969-75-9.gif)
101969-75-9
34 suppliers
$28.69/1g
Yield: 100%
Reaction Conditions:
with aluminum (III) chloride in toluene at 130; for 2 h;Inert atmosphere;
Steps:
1.4. General method for demethylation of 3b, 3d-l and 3n-p with aluminum trichloride (4b, 4d-l and 4n-p).[10]
General procedure: AlCl3 (2.5 equiv.) was slowly added to a solution of 3b, 3d-l and 3n-p (1.0 equiv.) in toluene (0.15 M) under a N2 atmosphere. The mixture was refluxed at 130 °C for 2 h and by TLC (Pet. ether/EtOAc 4/1) full conversion was shown. The cooled mixture was poured into an 3 M HCl (aq.) solution, the organics were extracted with ethyl acetate (3 times), washed with brine, dried over MgSO4 and concentrated to give the desired 4-(benzoyl)phenols (4b, 4d-l and 4n-p) as solids.
References:
Yu, Zhiyi;Van Veldhoven, Jacobus P.D.;'T Hart, Ingrid M.E.;Kopf, Adrian H.;Heitman, Laura H.;Ijzerman, Adriaan P. [European Journal of Medicinal Chemistry,2015,vol. 106,p. 50 - 59] Location in patent:supporting information
![1-ETHYNYL-2-FLUOROBENZENE](/CAS/GIF/766-49-4.gif)
766-49-4
162 suppliers
$10.00/1g
![1,4-Benzoquinone](/CAS/GIF/106-51-4.gif)
106-51-4
478 suppliers
$10.00/5g
![2-FLUORO-4'-HYDROXYBENZOPHENONE](/CAS/GIF/101969-75-9.gif)
101969-75-9
34 suppliers
$28.69/1g
![Anisole](/CAS/GIF/100-66-3.gif)
100-66-3
510 suppliers
$10.00/5G
![2-FLUORO-4'-HYDROXYBENZOPHENONE](/CAS/GIF/101969-75-9.gif)
101969-75-9
34 suppliers
$28.69/1g
![2-Fluorobenzoyl chloride](/CAS/GIF/393-52-2.gif)
393-52-2
380 suppliers
$10.00/25g
![2-FLUORO-4'-HYDROXYBENZOPHENONE](/CAS/GIF/101969-75-9.gif)
101969-75-9
34 suppliers
$28.69/1g