2-Fluoro-4-methoxybenzoylchloride synthesis
- Product Name:2-Fluoro-4-methoxybenzoylchloride
- CAS Number:321-24-4
- Molecular formula:C8H6ClFO2
- Molecular Weight:188.58
394-42-3
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$21.21/1gm:
321-24-4
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$45.00/50mg
Yield: 94%
Reaction Conditions:
with sulfuryl dichlorideReflux;Inert atmosphere;
Steps:
a 2-fluoro-4-methoxybenzoyl chloride (Compound B)
Starting compound A (2-fluoro-4-methoxybenzoic acid, Aldrich) (350 g, 2.06 vmol) in SOCl2 (2500 ml) was refluxed under N2 overnight.The reaction was monitored by TLC (72h).The desired intermediate B was distilled from the reaction mixture (140°C, 10 mmHg) as white solid (365 g, yield: 94%).
References:
Johann Wolfgang Goethe-Universität;GenKyoTex SA;Brandes, Ralf;Schröder, Katrin;Page, Patrick;Laleu, Benoît;Gaggini, Francesca EP2591782, 2013, A1 Location in patent:Paragraph 0119;0120
74457-86-6
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$6.00/5g
321-24-4
99 suppliers
$45.00/50mg
372-20-3
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$7.00/5g
321-24-4
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$45.00/50mg
121219-03-2
271 suppliers
$13.00/5g
321-24-4
99 suppliers
$45.00/50mg
82380-18-5
326 suppliers
$8.00/5g
321-24-4
99 suppliers
$45.00/50mg