ChemicalBook CAS DataBase List 2-Fluoro-4-methoxybenzoylchloride

2-Fluoro-4-methoxybenzoylchloride synthesis

6synthesis methods

Product Name:2-Fluoro-4-methoxybenzoylchloride
CAS Number:321-24-4
Molecular formula:C8H6ClFO2
Molecular Weight:188.58

394-42-3 Synthesis

394-42-3
203 suppliers
$21.21/1gm:

321-24-4
100 suppliers
$45.00/50mg

Yield: 94%

Reaction Conditions:

with sulfuryl dichlorideReflux;Inert atmosphere;

Steps:

a 2-fluoro-4-methoxybenzoyl chloride (Compound B)
Starting compound A (2-fluoro-4-methoxybenzoic acid, Aldrich) (350 g, 2.06 vmol) in SOCl₂ (2500 ml) was refluxed under N₂ overnight.The reaction was monitored by TLC (72h).The desired intermediate B was distilled from the reaction mixture (140°C, 10 mmHg) as white solid (365 g, yield: 94%).

References:

Johann Wolfgang Goethe-Universität;GenKyoTex SA;Brandes, Ralf;Schröder, Katrin;Page, Patrick;Laleu, Benoît;Gaggini, Francesca EP2591782, 2013, A1 Location in patent:Paragraph 0119;0120

74457-86-6 Synthesis