2-FLUORO-5-METHOXYBENZONITRILE synthesis
- Product Name:2-FLUORO-5-METHOXYBENZONITRILE
- CAS Number:127667-01-0
- Molecular formula:C8H6FNO
- Molecular Weight:151.14
796120-91-7
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Yield: 11 g
Reaction Conditions:
with triethylamine;trifluoroacetic anhydride in tetrahydrofuran
Steps:
1.3 (3) Synthesis of 2-Fluoro-5-methoxybenzonitrile
15 g of 2-fluoro-5-methoxybenzaldehyde oxime was added to 150 ml of tetrahydrofuran,Add 40g of trifluoroacetic anhydride,Then add 20ml triethylamine,concentrate,Add water and ethyl acetate to extract,Collect the organic phase,dry,concentrate,The residue was separated on a silica gel column to give 11 g of 2-fluoro-5-methoxybenzonitrile.
References:
Hunan Huateng Pharmaceutical Co., Ltd.;Bu Gonggaofamingren CN107778264, 2018, A Location in patent:Paragraph 0029; 0030
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