2-Fluorobenzenesulfonyl Fluoride synthesis
- Product Name:2-Fluorobenzenesulfonyl Fluoride
- CAS Number:52200-99-4
- Molecular formula:C6H4F2O2S
- Molecular Weight:178.16
2905-21-7
217 suppliers
$9.00/5g
52200-99-4
38 suppliers
$75.00/100mg
Yield:52200-99-4 89%
Reaction Conditions:
with potassium fluoride;18-crown-6 ether in acetonitrile at 20;
Steps:
Preparation of reagent R-02b: 4-Fluorobenzenesulfonyl fluoride.
Preparation of reagent R-02b: 4-Fluorobenzenesulfonyl fluoride. To a solution of compound 2-Fluorobenzenesulfonyl chloride (4 g, 20 mmol) and KF (3.5 g, 60 mol), 18-crown-6 (1 g) in ACN (50 ml_) was stirred at r.t overnight. The mixture was quenched with aqueous H2O and extracted with EtOAc, the organic layer was washed with brine, dried over anhydrous Na2SO4, concentrated to give the crude product which was purified by column chromatography to give pure compound 150-1 (4 g, 89%) as a pale yellow oil. GC-MS (M+1 ): 179 calc. for C6H4F2O2S.
References:
WO2015/104343,2015,A1 Location in patent:Page/Page column 62
348-54-9
412 suppliers
$10.00/1g
52200-99-4
38 suppliers
$75.00/100mg
115560-96-8
9 suppliers
$143.00/1g
52200-99-4
38 suppliers
$75.00/100mg
6461-76-3
85 suppliers
$45.00/50mg
52200-99-4
38 suppliers
$75.00/100mg