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84944-15-0

[(2-fluorophenyl)amino](oxo)acetic acid synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h / 0 - 20 °C
2: aq. LiOH / dioxane / 1 h / 20 °C

References:

Linton, Steven D.;Aja, Teresa;Armstrong, Robert A.;Bai, Xu;Chen, Long-Shiuh;Chen, Ning;Ching, Brett;Contreras, Patricia;Diaz, Jose-Luis;Fisher, Craig D.;Fritz, Lawrence C.;Gladstone, Patricia;Groessl, Todd;Gu, Xin;Herrmann, Julia;Hirakawa, Brad P.;Hoglen, Niel C.;Jahangiri, Kathy G.;Kalish, Vincent J.;Karanewsky, Donald S.;Kodandapani, Lalitha;Krebs, Joseph;McQuiston, Jeff;Meduna, Steven P.;Nalley, Kip;Robinson, Edward D.;Sayers, Robert O.;Sebring, Kristen;Spada, Alfred P.;Ternansky, Robert J.;Tomaselli, Kevin J.;Ullman, Brett R.;Valentino, Karen L.;Weeks, Suzanne;Winn, David;Wu, Joe C.;Yeo, Pauline;Zhang, Cheng-Zhi [Journal of Medicinal Chemistry,2005,vol. 48,# 22,p. 6779 - 6782]

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