2-Furancarboxylic acid, 4-(1,1-dimethylethyl)- synthesis

5synthesis methods

Product Name:2-Furancarboxylic acid, 4-(1,1-dimethylethyl)-
CAS Number:59414-09-4
Molecular formula:C9H12O3
Molecular Weight:168.19

2-Furancarboxylic acid, 5-bromo-4-(1,1-dimethylethyl)-

59413-67-1
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2-Furancarboxylic acid, 4-(1,1-dimethylethyl)-

59414-09-4
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Yield:-

Reaction Conditions:

with ammonia;zinc in water;

Steps:

L 4-tert-butyl-furan-2-carboxylic acid

Example L 4-tert-butyl-furan-2-carboxylic acid The title compound was prepared according to the procedure as described in Gilman, H., et al., J. Am. Chem. Soc., 1935, Vol. 57, pp 909-912, more particularly, as described on page 910) by treating a dilute aqueous NH₃ solution (made by dilution of 1 mL of 29.3% aqueous NH₃ with 9 mL of H₂O) of 5-bromo-4-tert-butyl-furan-2-carboxylic acid (500 mg, 2.02 mmol, prepared as described in Example K, Step B) with Zn dust (265 mg, 4.05 mmol) to yield the title compound. ¹H-NMR (400 MHz, CDCl₃) δ: 7.40 (d, J=1.0 Hz, 1H), 7.28 (d, J=1.2 Hz, 1H), 1.26 (s, 9H).

References:

US2011/218197,2011,A1 Location in patent:Page/Page column 48

6132-37-2 Synthesis