2-Hexanone, 4-hydroxy-, (S)- (9CI) synthesis

4synthesis methods

Product Name:2-Hexanone, 4-hydroxy-, (S)- (9CI)
CAS Number:181185-39-7
Molecular formula:C6H12O2
Molecular Weight:116.1583

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Yield:181185-39-7 80%

Reaction Conditions:

with hexakis[6-deoxy-6-amino]-α-cyclodextrin in water at 15; for 6 h;Aldol Condensation;

Steps:

5 Asymmetric Aldol reaction catalyzed by all-(6-amino)-α-cyclodextrin

Add 193.3mg (0.2mmol) of all-(6-amino)-α-cyclodextrin into 2mL pure water,Then add 74μL (1mmol) of acetone,58mg (1mmol) of propionaldehyde, stirred at 15°C for 6h; then added ethyl acetate for extraction, the organic layer was washed with water and saturated brine successively, then dried by adding anhydrous sodium sulfate, spin-dried; separated and purified by silica gel column The final pure product is 92.8 mg, the yield is 80%, and the ee value is 95%

References:

CN112266327,2021,A Location in patent:Paragraph 0046-0047