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ChemicalBook CAS DataBase List 2-Hydroxy-D-phenylalanine
24008-77-3

2-Hydroxy-D-phenylalanine synthesis

2synthesis methods
-

Yield:72 % ee

Reaction Conditions:

Stage #1: o-Coumaric acidwith ammonium hydroxide;phenylalanine ammonia-lyase from Anabaena variabilis N347A mutant in aq. buffer at 35; pH=8.5; for 12 h;
Stage #2: with borane-ammonia complex;L-amino acid deaminase from Proteus mirabilis in aq. buffer at 35; pH=8.5; for 12 h;stereoselective reaction;

References:

Zhu, Longbao;Feng, Guoqiang;Ge, Fei;Song, Ping;Wang, Taotao;Liu, Yi;Tao, Yugui;Zhou, Zhemin [Applied Biochemistry and Biotechnology,2018,p. 1 - 15]

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