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2-isopropoxynicotinonitrile synthesis
- Product Name:2-isopropoxynicotinonitrile
- CAS Number:75424-70-3
- Molecular formula:C9H10N2O
- Molecular Weight:162.19
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Yield:75424-70-3 94%
Reaction Conditions:
with potassium hydroxide;18-crown-6 ether in toluene at 60; for 16 h;
Steps:
31
Example 31 N4-[(trans-4-aminocyclohexyl)methyl]-N2-[(2-isopropoxypyridin-3-yl)methyl]-5-nitropyrimidine-2,4-diamine A mixture of 2-chloronicotinonitrile (1.0 g, 7.2 mmol), 2-propanol (0.87 g, 14.4 mmol), KOH (0.81 g, 14.4 mmol) and 18-crown-6 (1.8 g, 2.89 mmol) in toluene (30 mL) was stirred at 60° C. for 16 h. The reaction mixture was quenched with water and the organic phase was separated and then washed with water (*5). The organic phase was dried over Na2SO4 and concentrated to yield crude 2-isopropoxy-nicotinonitrile (1.1 g, 94%) which was used without further purification.
References:
US2006/25433,2006,A1 Location in patent:Page/Page column 119
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