2-METHOXY-3-THENOYLPYRIDINE synthesis
- Product Name:2-METHOXY-3-THENOYLPYRIDINE
- CAS Number:332134-11-9
- Molecular formula:C11H9NO2S
- Molecular Weight:219.26
1628-89-3
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$17.96/25g
5271-67-0
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$5.00/1g
332134-11-9
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$478.00/1g
Yield:332134-11-9 85%
Reaction Conditions:
Stage #1: 2-methoxypyridinewith aluminum tris-(tert-butyl-(1-isopropyl-2,2-dimethyl-propyl)amide)-tris(lithium chloride) in tetrahydrofuran at 25; for 3 h;Inert atmosphere;
Stage #2: with zinc(II) chloride in tetrahydrofuran at -30; for 0.25 h;Inert atmosphere;
Stage #3: 2-Thiophenecarbonyl chloridewith copper(I) cyanide*2 lithium chloride in tetrahydrofuran at -30 - 25;Inert atmosphere;regioselective reaction;
References:
Wunderlich, Stefan H.;Knochel, Paul [Angewandte Chemie - International Edition,2009,vol. 48,# 8,p. 1501 - 1504] Location in patent:supporting information; experimental part
125035-34-9
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$512.00/1g
332134-11-9
9 suppliers
$478.00/1g
49609-84-9
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$20.00/5g
332134-11-9
9 suppliers
$478.00/1g