2-Methoxy-4-(1H-tetrazol-5-yl)phenol synthesis

Yield:376609-66-4 89%

Reaction Conditions:

with sodium azide;hydroxylamine hydrochloride in N,N-dimethyl-formamide at 80; for 3.4 h;

Steps:

The general method for the synthesis of 5-substituted 1H-tetrazole derivatives

General procedure: combination of sodium azide (1.5 mmol), aromatic aldehyde (1 mmol),hydroxylamine (1.2 mmol), and MNC-Cu (0.26 mol% ? 0.01 g) with 5 mLDMF was and stirred at 80 °C for the various time with heating (Table 2). Theproceeding of the reaction was observed by thin-layer chromatography (TLC).After completing the reaction and cooling to ambient temperature, the fabricatedcatalyst was magnetically separated by an external magnet. After removing thecatalyst, the remaining mixture’s solvents were eliminated under reduced pressureand then dissolved in water. Afterward, HCl (15 mL, 2 N) was added tothe aqueous solution to obtain a powder form of the tetrazole derivatives. The precipitate was filtered and crystallized from a mixture of ethanol and water, andthere was no need for further purification process via this route

References:

Tahmasbi, Marzieh;Akbarzadeh, Parisa;Koukabi, Nadiya [Research on Chemical Intermediates,2022,vol. 48,# 4,p. 1383 - 1401]