2-METHOXY-4-FORMYLPHENOXY-BUTYRIC ACID synthesis
- Product Name:2-METHOXY-4-FORMYLPHENOXY-BUTYRIC ACID
- CAS Number:174358-69-1
- Molecular formula:C12H14O5
- Molecular Weight:238.24
Yield:174358-69-1 45%
Reaction Conditions:
with potassium carbonate in acetone at 20;
Steps:
3 Example 3- preparation of 4-(4-formyl-2-methoxyphenoxy)butyric acid
3g vanillin was dissolved in 30mL of anhydrous acetone,Add anhydrous potassium carbonate 5g,Slowly added at room temperatureEthyl bromobutyrate3.85g,Then, the mixture was stirred at room temperature overnight, filtered, spun dry acetone, dissolved in 30 mL of methanol, added with 20 mL of 10% sodium hydroxide solution, hydrolyzed overnight with 10% hydrochloric acid to adjust the pH to acidic, extracted with dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate The organic layer was spin-dried, recrystallized from methanol to give a pale yellow solid 2.11g, yield 45%.
References:
CN104447322,2018,B Location in patent:Paragraph 0071-0073
176375-41-0
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