ChemicalBook CAS DataBase List 2-Methoxy-4-methyl-5-pyrimidinamine

2-Methoxy-4-methyl-5-pyrimidinamine synthesis

4synthesis methods

Product Name:2-Methoxy-4-methyl-5-pyrimidinamine
CAS Number:908099-97-8
Molecular formula:C6H9N3O
Molecular Weight:139.16

4-chloro-2-methoxy-6-methyl-5-nitropyrimidine

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908099-97-8
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Yield:908099-97-8 86%

Reaction Conditions:

with hydrogen;triethylamine in methanol at 50; under 22502.3 Torr; for 5 h;Autoclave;Temperature;Solvent;

Steps:

1-6

Add 8 g (0.04 mol, 1.0 eq) of 2-methoxy-5-nitro-4-methyl-6-chloropyrimidine to the autoclave,Add 80 ml of methanol, 0.4 g of nickel, 6 g (0.06 mol, 1.5 eq) of triethylamine, add hydrogen gas at 50°C and 3.0 MPa, and stir for 5 h.After the reaction is completed, filter, concentrate the filtrate, add 20ml of water, hot extract with EA, dry, freeze treatment,The product 2-methoxy-5-amino-4-methylpyrimidine 4.8g,GC: 98%, yield 86%.

References:

CN111253321,2020,A Location in patent:Paragraph 0015-0042

67-56-1 Synthesis