![](/CAS/20150408/GIF/908099-97-8.gif)
2-Methoxy-4-methyl-5-pyrimidinamine synthesis
- Product Name:2-Methoxy-4-methyl-5-pyrimidinamine
- CAS Number:908099-97-8
- Molecular formula:C6H9N3O
- Molecular Weight:139.16
![4-chloro-2-methoxy-6-methyl-5-nitropyrimidine](/CAS/GIF/84538-47-6.gif)
84538-47-6
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![2-Methoxy-4-methyl-5-pyrimidinamine](/CAS/20150408/GIF/908099-97-8.gif)
908099-97-8
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$97.00/100mg
Yield:908099-97-8 86%
Reaction Conditions:
with hydrogen;triethylamine in methanol at 50; under 22502.3 Torr; for 5 h;Autoclave;Temperature;Solvent;
Steps:
1-6
Add 8 g (0.04 mol, 1.0 eq) of 2-methoxy-5-nitro-4-methyl-6-chloropyrimidine to the autoclave,Add 80 ml of methanol, 0.4 g of nickel, 6 g (0.06 mol, 1.5 eq) of triethylamine, add hydrogen gas at 50°C and 3.0 MPa, and stir for 5 h.After the reaction is completed, filter, concentrate the filtrate, add 20ml of water, hot extract with EA, dry, freeze treatment,The product 2-methoxy-5-amino-4-methylpyrimidine 4.8g,GC: 98%, yield 86%.
References:
CN111253321,2020,A Location in patent:Paragraph 0015-0042
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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![5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)](/CAS/GIF/20090-69-1.gif)
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![2-Methoxy-4-methyl-5-pyrimidinamine](/CAS/20150408/GIF/908099-97-8.gif)
908099-97-8
36 suppliers
$97.00/100mg
![2,4-Dichloro-6-methyl-5-nitropyrimidine](/CAS/GIF/13162-26-0.gif)
13162-26-0
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$8.00/1g
![2-Methoxy-4-methyl-5-pyrimidinamine](/CAS/20150408/GIF/908099-97-8.gif)
908099-97-8
36 suppliers
$97.00/100mg
![5-Pyrimidinamine, 2-chloro-4-methyl- (9CI)](/CAS/GIF/20090-69-1.gif)
20090-69-1
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124-41-4
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$12.00/25g
![2-Methoxy-4-methyl-5-pyrimidinamine](/CAS/20150408/GIF/908099-97-8.gif)
908099-97-8
36 suppliers
$97.00/100mg