(2-METHOXY-5-TRIFLUOROMETHOXY-PHENYL)-METHANOL synthesis

Yield:562840-50-0 95%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 20;

Steps:

207 Preparation 207 (2-Methoxy-5-trifluoromethoxy-phenyl)-methanol

Dissolve 2-methoxy-5-trifluoromethoxy benzaldehyde (3.0 g, 13.6 mmol) in MeOH (50 mL) and add sodium borohydride (0.26 g, 6.88 mmol) and stir the mixture at RT until reduction is complete. Concentrate the mixture and dissolve the residue in CH2CI2. Wash with IN NAOH, water, and brine, dry over sodium sulfate, filter, and concentrate. Purify the residue by chromatography over silica gel using a MEOH/CH2CI2 gradient to provide the title compound (2.88 g, 95 %) as a clear oil. MS (EI) 222.1 (M) + ; RF= 0.28 (CH2C12).

References:

WO2005/821,2005,A1 Location in patent:Page 49