2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL synthesis
- Product Name:2-METHOXY-5-(TRIFLUOROMETHYL)PHENOL
- CAS Number:349-67-7
- Molecular formula:C8H7F3O2
- Molecular Weight:192.14
240139-82-6
98 suppliers
$24.00/1g
349-67-7
38 suppliers
$45.00/50mg
Yield:349-67-7 95%
Reaction Conditions:
with dihydrogen peroxide in ethanol at 80; for 2 h;
Steps:
27.1 Synthesis of 2-methoxy-5-(trifluoromethyl)phenol
Into a 100-mL round-bottom flask, were placed [2-methoxy-5-(trifluoromethyl) phenyl] boronic acid (300 mg, 1 .36mmol, 1 .00 equiv), ethanol (15m l_), H202 (aq 30%) (2m l_).The resulting reaction was stirred for 2 h at 80°C. The resulting mixture was concentrated in vacuo. The reaction was then diluted by the addition of water. The resulting mixture was washed with Na2S03 (aq). The aqueous layer was extracted with ethyl acetate and the organic layers combined. The resulting mixture was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. This resulted in 250 mg (95%) of 2-methoxy-5-(trifluoromethyl)phenol as a colorless oil.
References:
WO2015/130957,2015,A1 Location in patent:Page/Page column 85
402-52-8
131 suppliers
$14.00/1g
349-67-7
38 suppliers
$45.00/50mg