2-Methoxy-6-(Methylsulfonyl)aniline synthesis

6synthesis methods

Product Name:2-Methoxy-6-(Methylsulfonyl)aniline
CAS Number:148726-71-0
Molecular formula:C8H11NO3S
Molecular Weight:201.24

4920-80-3
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148726-71-0
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: SOCl₂
2: 1.) NaN₃, 2.) H₂O, 4.) NaOH, 5.) HCl
3: 1.) 98percent sulfuric acid, NaNO₂, 2.) CuCl₂, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h
4: 35 percent / dimethylformamide; H₂O / 2 h / 100 °C
5: 61 percent / mcpba / CH₂Cl₂ / Ambient temperature
6: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

References:

Kimura;Watanabe;Matsui;Hayashi;Tanaka;Ohtsuka;Saeki;Kogushi;Kabayashi;Akasaka;Yamagishi;Saitou;Yamatsu [Journal of Medicinal Chemistry,1993,vol. 36,# 11,p. 1641 - 1653]

148726-67-4 Synthesis

1-Methoxy-3-(Methylsulfonyl)-2-nitrobenzene

148726-67-4
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References

5472-99-1 Synthesis

5472-99-1
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References

16554-47-5
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References

15865-57-3
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References