2-METHOXYMETHYL METHANSULFONATE synthesis
- Product Name:2-METHOXYMETHYL METHANSULFONATE
- CAS Number:16427-44-4
- Molecular formula:C4H10O4S
- Molecular Weight:154.18
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16427-44-4
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Yield: 98%
Reaction Conditions:
in dichloromethane at 10 - 20; for 4 h;
Steps:
1.1
Example 1-(1); Synthesis of Ethylene Glycol Monomethyl Ether Methanesulfonate; 1-Methylimidazole (50 g) and methanesulfonyl chloride (66 g) were mixed in dichloromethane in a 500 mL two-bulb flask. After adding ethylene glycol monomethyl ether (42 g) dropwise at 10° C., the mixture was stirred at room temperature for 4 hours. After the reaction was completed, water was added. After stirring for 10 minutes, the solvent layer in which the product was dissolved was separated from the aqueous layer in which the byproduct was dissolved. The product was yielded by removing the solvent at room temperature using an evaporator (yield: 98%), and the byproduct 1-methylimidazolium chloride was recovered as 1-methylimidazole using 40 wt % NaOH aqueous solution and used again (yield: 95%).
References:
Korea Institute of Science and Technology US2012/83642, 2012, A1 Location in patent:Page/Page column 4