2-Methyl-2-(2-nitrophenyl)propanoicacid synthesis
- Product Name:2-Methyl-2-(2-nitrophenyl)propanoicacid
- CAS Number:126802-52-6
- Molecular formula:C10H11NO4
- Molecular Weight:209.2
136764-87-9
32 suppliers
inquiry
126802-52-6
18 suppliers
inquiry
Yield: 94%
Reaction Conditions:
with water;sodium hydroxide in methanol for 48 h;Reflux;
Steps:
1.1
he above-mentioned product 10.5g soluble in 100 ml, the volume ratio of methanol: water=1:1 solution, adding 8M of sodium hydroxide solution 20 ml, reflux 48 hours, TLC monitoring completion of the reaction, by adding 1M hydrochloric acid, the PH is adjusted to 2 - 3, by adding dichloromethane extraction 3 times, collecting the organic phase, dried with anhydrous sodium sulfate, concentrated under reduced pressure, column chromatography 9.2g, the yield is 94%
References:
Jiangxi Normal University;Sun Jiansong;Liu Hui;Liao Jinxi CN106831436, 2017, A Location in patent:Paragraph 0017; 0018; 0021
1195-98-8
97 suppliers
inquiry
126802-52-6
18 suppliers
inquiry