2-methyl-2-(5-methylpyridin-2-yloxy)propanoic acid synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: cesium carbonate / acetonitrile / 50 °C
2: aq. sodium hydroxide / acetonitrile / 50 °C

References:

Liu, Ping;Lin, Linus S.;Hamill, Terence G.;Jewell, James P.;Lanza Jr., Thomas J.;Gibson, Raymond E.;Krause, Stephen M.;Ryan, Christine;Eng, Waisi;Sanabria, Sandra;Tong, Xinchun;Wang, Junying;Levorse, Dorothy A.;Owens, Karen A.;Fong, Tung M.;Shen, Chun-Pyn;Lao, Julie;Kumar, Sanjeev;Yin, Wenji;Payack, Joseph F.;Springfield, Shawn A.;Hargreaves, Richard;Burns, H. Donald;Goulet, Mark T.;Hagmann, William K. [Journal of Medicinal Chemistry,2007,vol. 50,# 15,p. 3427 - 3430]

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