(2-methyl-2-pyrrolidinyl)methanol(SALTDATA: FREE) synthesis
- Product Name:(2-methyl-2-pyrrolidinyl)methanol(SALTDATA: FREE)
- CAS Number:955029-45-5
- Molecular formula:C6H13NO
- Molecular Weight:115.17
1290048-17-7
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955029-45-5
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Yield:955029-45-5 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol; for 0.5 h;
Steps:
37 (rac)-(2-Methyl-pyrrolidin-2-yl)-methanol
(rac)-(2-Methyl-pyrrolidin-2-yl)-methanol 1.6 g (6.4 mmol) of 2-Hydroxymethyl-2-methyl-pyrrolidine-1-carboxylic acid benzyl ester (WO2008/81910 A1) was dissolved in 10 ml MeOH, 0.1 g of 10% palladium on charcoal was added and the mixture stirred under an atmosphere of hydrogen (ballon) for 30 minutes. The reaction is then filtered through Hyflo and concentrated affording the titled compound in quantitative yield as white foam. 1H-NMR (300 MHz, DMSO-d6): 3.1 (s, 2H), 2.83-2.74 (m, 2 H), 1.68-1.60 (m, 4H), 0.98 (s, 3H).
References:
US2011/92698,2011,A1 Location in patent:Page/Page column 33
16277-06-8
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955029-45-5
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145681-01-2
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955029-45-5
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201406-78-2
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955029-45-5
11 suppliers
$90.00/50mg