ChemicalBook CAS DataBase List 2-Methyl-3-nitrobenzoic acid

2-Methyl-3-nitrobenzoic acid synthesis

11synthesis methods

Product Name:2-Methyl-3-nitrobenzoic acid
CAS Number:1975-50-4
Molecular formula:C8H7NO4
Molecular Weight:181.15

83-41-0
7 suppliers
$13.00/25g

1975-50-4
438 suppliers
$18.00/25g

Yield:1975-50-4 87%

Reaction Conditions:

with dihydrogen peroxide;cobalt(II) acetate;manganese(II) acetate;hexanoic acid at 60; for 12 h;Temperature;Reagent/catalyst;

Steps:

1-14 Example 2:
In a 500 ml three-necked flask, 20 g of 3-nitro-o-xylene (0.132 mol) was added.0.1211 g of manganese acetate (0.0007 mol), 0.0249 g of cobalt acetate (0.0001 mol),Then, 76 g (0.66 mol) of n-hexanoic acid was added, and 9.87 g (0.29 mol) of hydrogen peroxide was slowly added dropwise.Slowly raise the temperature to 60 ° C, keep the reaction for 12 hours, and measure the reaction by HPLC.When the raw material 3-nitro-o-xylene remains less than 2%,Adding 34 g (0.85 mol) of aqueous sodium hydroxide solution to the reaction system, and separating the liquid.The aqueous layer was adjusted to pH 2 with 32.8 g (0.90 mol) hydrochloric acid.The desired product of 2-methyl-3-nitrobenzoic acid was obtained by suction filtration (20.78 g, yield: 87%).

References:

Jiangsu Yong'an Chemical Co., Ltd.;Zhao Jianqiang;Zhang Guofu CN109824517, 2019, A Location in patent:Paragraph 0024-0047

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118-90-1 Synthesis