2-METHYL-3-(TRIFLUOROMETHYL)BENZALDEHYDE synthesis

Yield:-

Reaction Conditions:

with manganese(IV) oxide in dichloromethane for 72 h;

Steps:

To a sol. of 2-methyl-3-trifluoromethylbenzyl alcohol (0.500 g, 2.63 mmol) in CH₂Cl₂ (25 mL) was added activated MnO₂ (2.29 g, 26.3 mmol). After stirring for 72 h, the mixture was filtered over Celite, and the solvents were removed under reduced pressure. The aldehyde is used in the next step without further purification. 1H NMR (CDCl3) δ 10.40 (s, 1H), 8.00 (d, 1H), 7.85 (d, 1H), 7.45 (t, 1H), 2.8 (s, 3H).

References:

ACTELION PHARMACEUTICALS LTD. WO2006/21402, 2006, A1 Location in patent:Page/Page column 41

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