ChemicalBook CAS DataBase List 2-Methyl-4-(2-methylbenzamido)benzoic acid

2-Methyl-4-(2-methylbenzamido)benzoic acid synthesis

8synthesis methods

Product Name:2-Methyl-4-(2-methylbenzamido)benzoic acid
CAS Number:317374-08-6
Molecular formula:C16H15NO3
Molecular Weight:269.3

2486-75-1 Synthesis

2486-75-1
233 suppliers
$8.00/1g

933-88-0 Synthesis

933-88-0
334 suppliers
$10.00/1g

2-Methyl-4-(2-methylbenzamido)benzoic acid

317374-08-6
153 suppliers
$13.00/1g

Yield: 95.6%

Reaction Conditions:

with pyridine in chloroform at 0 - 40; for 8 h;Reagent/catalyst;Solvent;Temperature;

Steps:

4-5 Example 5: Preparation of 2-methyl-4-N-(2-methylbenzoyl)benzoic acid
2-Methyl-4-aminobenzoic acid (10 g) was dissolved in chloroform (150 ml).Further, pyridine (11.1 g) was added, and the reaction mixture was cooled to 0 to 5 ° C, and 2-methylbenzoyl chloride (12.2 g) was added dropwise.The temperature at the time of dropping was controlled to be 0 to 10 ° C, and after the completion of the dropwise addition, the temperature was raised to 40 ° C for 8 hours.After the reaction was completed, 150 ml of ice water was added, the layers were separated, and the chloroform layer was washed with water (100 ml).Dried over anhydrous sodium sulfate, filtered and evaporated to dryness under reduced pressure and chloroform, to give 2-methyl -4-N- (2- methylbenzoyl) benzoic acid.It was purified by a mixed solvent of ethyl acetate and ethanol to obtain a white solid (17.0 g, yield: 95.6%, purity 99.5%,

References:

Chongqing Changjie Pharmaceutical Co., Ltd.;Chongqing Shenghuaxi Pharmaceutical Co., Ltd.;Liu Jiabing;Huang Zhiwei CN109928890, 2019, A Location in patent:Paragraph 0021-0022