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ChemicalBook CAS DataBase List 2-METHYL-4-OXO-4-(4'-METHOXYPHENYL)BUTYRIC ACID

2-METHYL-4-OXO-4-(4'-METHOXYPHENYL)BUTYRIC ACID synthesis

6synthesis methods
-

Yield:5717-16-8 83%

Reaction Conditions:

Stage #1: carbon dioxidewith chloro-trimethyl-silane;magnesium in N,N-dimethyl-formamide at 20; under 760.051 Torr; for 0.5 h;Green chemistry;
Stage #2: 1-(4-methoxy-phenyl)-but-2-en-1-one in N,N-dimethyl-formamide at 0; for 1 h;Green chemistry;

References:

Zheng, Suhua;Zhang, Tianyuan;Maekawa, Hirofumi [Journal of Organic Chemistry,2022,vol. 87,# 11,p. 7342 - 7349]

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