ChemicalBook CAS DataBase List 2-Methyl-6-trifluoroMethyl-1H-indole

2-Methyl-6-trifluoroMethyl-1H-indole synthesis

5synthesis methods

Product Name:2-Methyl-6-trifluoroMethyl-1H-indole
CAS Number:57330-48-0
Molecular formula:C10H8F3N
Molecular Weight:199.17

1-(2-Nitro-4-trifluoroMethyl-phenyl)-propan-2-one

57330-58-2
9 suppliers
$240.00/1g

57330-48-0
33 suppliers
$130.00/50mg

Yield:57330-48-0 86%

Reaction Conditions:

with carbon monoxide;cyclopentadienyl iron(II) dicarbonyl dimer in toluene at 120; for 5 h;

Steps:

12

EXAMPLE 12 Synthesis of 2-methyl-6-trifluoromethylindole In a stainless steel autoclave having an internal volume of 100 mL, 1.26 g (5.1 mmol) of 2-nitro4-trifluoromethylphenylacetone, 72 mg (4 mol %) of cyclopentadienyldicarbonyliron (dimer) and 40 g of toluene were placed under nitrogen atmosphere. After the atmosphere inside of the reactor was substituted by nitrogen gas (10 kgf/cm2) three times, carbon monoxide gas was injected (30 kgf/cm2), and the resulting mixture was reacted at a temperature of 120 C. for 5 hours. After cooling, the reaction solution was subjected to quantitative analysis with liquid chromatography. As a result of it, it was confirmed that 5-fluoro-2-nitrophenylacetone was completely disappeared and 0.87 g (yield 86.0%) of 2-methyl-6-trifluoromethylindole was formed.

References:

US2007/83053,2007,A1 Location in patent:Page/Page column 7-8