(2-Methylbenzoimidazol-1-yl)acetic acid synthesis
- Product Name:(2-Methylbenzoimidazol-1-yl)acetic acid
- CAS Number:40332-17-0
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
Yield:40332-17-0 40.2%
Reaction Conditions:
in ethanol;water;Reflux;
Steps:
2.1
1) To a clean 100 mL three-necked flask was added 0.005 mol of 2-methylbenzimidazole in turn,20 mL of ethanol,0.007 mol of potassium chloroacetate,And dissolved in water,And then stir to warm up to the reflux state,The reaction process was monitored by TLC during the refluxing reaction,After completion of the reaction, the resulting reaction solution was cooled to room temperature,In the ice water bath with the concentration of 37.5% hydrochloric acidAdjust the pH of the reaction solution = 1-2,At this time a large number of solid precipitation,Filter,Recrystallization was carried out using a mixed solvent of ethanol and water in a volume ratio of 1: 1,After standing overnight,Dried to give 0.19 g of 1-carboxymethyl-2-methylbenzimidazole, and the developing agent used in TLC monitoring was a mixture of ethyl acetate and petroleum ether in a volume ratio of 1: 3;The yield was 40.2%
References:
CN104130249,2017,B Location in patent:Paragraph 0093
615-15-6
316 suppliers
$9.00/1g
40332-17-0
57 suppliers
$45.00/100mg
615-15-6
316 suppliers
$9.00/1g
79-11-8
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$27.00/25g
40332-17-0
57 suppliers
$45.00/100mg