2-(METHYLETHYL)PYRROLIDINE HYDROCHLORIDE synthesis

Yield:540526-01-0 94%

Reaction Conditions:

Stage #1: (2-(2-isopropylpyrrolidin-1-yl)-5-methoxyphenyl)methanolwith ammonium cerium (IV) nitrate in water;acetonitrile at 0 - 20; for 3 h;Inert atmosphere;
Stage #2: with hydrogenchloride in dichloromethane;water; pH=Ca. 2;Inert atmosphere;

References:

Jurberg, Igor D.;Peng, Bo;Woestefeld, Eckhard;Wasserloos, Maximilian;Maulide, Nuno [Angewandte Chemie - International Edition,2012,vol. 51,# 8,p. 1950 - 1953] Location in patent:supporting information; experimental part