ChemicalBook CAS DataBase List 2-METHYLPHENYLBORONIC ACID, PINACOL ESTER

2-METHYLPHENYLBORONIC ACID, PINACOL ESTER synthesis

12synthesis methods

Product Name:2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
CAS Number:195062-59-0
Molecular formula:C13H19BO2
Molecular Weight:218.1

73183-34-3
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133-59-5 Synthesis

133-59-5
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2-METHYLPHENYLBORONIC ACID, PINACOL ESTER

195062-59-0
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Yield: 92.5%

Reaction Conditions:

with 2,2'-azobis[2-[1-(2-hydroxyethyl)-2-imidazolin-2-yl]propane] dihydrochloride in water at 100; for 2 h;Temperature;Reagent/catalyst;

Steps:

6; 7
Add 100ml of water, 0.1mol of o-toluenesulfonyl chloride, and 0.2mol of bis(pinacolato)diboron to the reaction flask, and stir thoroughly, then add 0.01mol 2,2'-azobis[2-[1-(2-hydroxyethyl)-2-imidazolin-2-yl]propane] dihydrochloride, slowly increase the temperature to 100°C, keep the temperature for 2h, the whole reaction process is in a stirring state, after the reaction, the system was slowly cooled to room temperature, extracted with dichloromethane three times, the organic phase was collected, distilled under reduced pressure, and dried in vacuum, a white solid o-toluene boronic acid pinacol ester was obtained with a yield of 92.5% and a purity of 95.8%.

References:

Shandong Zhuojun Industrial Co., Ltd.;Li Juan;Yuan Xiaodan CN111793080, 2020, A Location in patent:Paragraph 0052-0053; 0054-0055

95-49-8 Synthesis