2-MORPHOLIN-4-YL-1-PHENYLETHYLAMINE synthesis
- Product Name:2-MORPHOLIN-4-YL-1-PHENYLETHYLAMINE
- CAS Number:38060-08-1
- Molecular formula:C12H18N2O
- Molecular Weight:206.29
877125-77-4
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38060-08-1
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Yield:-
Reaction Conditions:
Stage #1: 2-amino-1-morpholin-4-yl-2-phenylethanonewith lithium aluminium tetrahydride in tetrahydrofuran at 0; for 2 h;Heating / reflux;
Stage #2: with water;sodium sulfate in tetrahydrofuran at 0 - 20; for 0.5 h;
Steps:
1.1.3
To a stirred suspension of LAH (6.1 mmol) in THF (25 mL) is added dropwise a solution of 2-amino-1-morpholin-4-yl-2-phenylethanone (670 mmol) in THF (5 ml) at 0 °C. The reaction mixture is refluxed for 2 hr, and then the reaction is quenched by the addition of Na2S04-10H2O at 0 °C. After stirring at room temperature for 0.5 h, the resulting mixture is filtered through celite, and the filtrate is concentrated in vacuo to give the title compound, which is directly used for the next reaction without further purification.
References:
WO2006/18284,2006,A1 Location in patent:Page/Page column 51
15437-09-9
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38060-08-1
38 suppliers
$45.00/50mg